Department of Otolaryngology

Srivatsun Sadagopan, PhD

  • Assistant Professor, Department of Otolaryngology

Education & Training

  • 2011 – 2015 Postdoctoral associate, The Rockefeller University
  • 2008 – 2011 Postdoctoral associate, Northwestern University
  • 2001 – 2008 PhD in Neuroscience, The Johns Hopkins University School of Medicine
  • 1997 – 2001 Bachelor of Technology (Hons.), Indian Institute of Technology

Representative Publications

Sadagopan S*, Temiz-Karayol NZ & Voss HU (2015). High-field functional magnetic resonance imaging of vocalization processing in marmosets. Scientific Reports 5: 10950, doi: 10.1038/srep10950 (*Corresponding author).

Sadagopan S & Ferster D (2012). Feedforward origins of response variability underlying contrast invariant orientation tuning in cat visual cortex. Neuron 74: 911 – 23.

Bartlett EL*, Sadagopan S* & Wang X (2011). Fine frequency tuning in monkey auditory cortex and thalamus. The Journal of Neurophysiology 106: 849 – 59. (*equal contribution)

Sadagopan S & Wang X (2010). Contribution of inhibition to stimulus selectivity in the primary auditory cortex of awake primates. The Journal of Neuroscience 30: 7314 – 25.

Sadagopan S & Wang X (2009). Nonlinear receptive fields underlie feature selectivity in primary auditory cortex. The Journal of Neuroscience 29: 11192 – 202.

Sadagopan S & Wang X (2008). Level invariant representation of sounds by populations of neurons in primary auditory cortex. The Journal of Neuroscience 28: 3415 – 26.

View Dr. Sadagopan's most current publications.

Research Interest Summary

Structure and function of auditory cortex, Computational neuroscience

Research Interests

Dr. Sadagopan joined the Auditory Research Group in January 2015. His research focuses on the neural mechanisms by which stable perception of complex sounds, such as speech, is maintained in the face of highly variable environmental conditions. Dr. Sadagopan uses electrophysiological, pharmacological and computational methods to address these questions using Guinea pigs as a model system. In particular, he is interested in the role that cortical inhibition plays in ensuring stable stimulus representations. Realistic listening conditions pose a significant challenge to patients with communication disorders such as dyslexia, some sensory aphasias, to the hearing impaired, and to the elderly with age-related decline in hearing. Research in his laboratory might provide fundamental insights into these disorders by understanding the basic mechanisms by which the brain extracts meaningful signals from noise.

Research Grants

Cortical processing of communication sounds in realistic listening conditions, Aug 2015 – July 2016, Pennsylvania Lions Hearing Research Foundation, Competitive external award

Developing optogenetic methods to probe the role of cortical inhibition in real-world sound perception, Aug 2015 – July 2016, Samuel and Emma Winters Foundation, Competitive external award